In 2018, PAS Center together with implementing partners have designed a new regional project (TB-REP 2.0) to advance towards people-centered approaches ensuring provision of quality TB and DR-TB care and prevention in EECA region, based on previous experience and lessons learned from the implementation of the regional TB-REP program designed to contribute to strengthening health systems’ responses to TB in the longer term. The overall goal of TB-REP 2.0 is to foster timely TB case detection and improved treatment outcomes in patients with special emphasis on drug-resistant TB, in eleven EECA countries through meaningful involvement of communities and civil society and integrated people-centered TB care delivery systems able to address the needs of key and vulnerable populations. The program incorporates the full spectrum of DR-TB prevention and care issues, targeting both health and sustainable community systems for improved quality and strengthened people-centered approaches in TB care delivery.